Category Archives: Research

PAVE the way to a better quality of life on haemodialysis

(Paclitaxel assisted balloon Angioplasty of Venous Stenosis in haEmodialysis access) The PAVE Trial is a randomised controlled trial (people taking part are put into one or other group at random – see below). It aims to preserve arteriovenous fistulae (AVF), used for haemodialysis. We plan to start recruiting haemodialysis patients in October 2015. Vascular access for haemodialysis Haemodialysis requires access to the circulation (blood stream)…

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PIVOTAL (Proactive IV irOn Therapy in haemodiALsis patients)

People with kidney failure do not make enough erythropoietin (EPO), a hormone that triggers the bone marrow to produce red blood cells. Haemodialysis patients are also deficient in iron as it is lost during dialysis and patients are unable to absorb enough in their diet. Iron makes up the haemoglobin in the red blood cells which transports oxygen around the body. Therefore, one of the…

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Latest Research into Adult Polycystic Kidney Disease (ADPKD)

This comes in all sizes, shapes and flavours. Sometimes it is about how genes contribute to diseases, sometimes it is about how certain drugs work, and sometimes it is a direct question “will this treatment help prevent or cure this disease”?  All of these types of research are important – without the basic understanding of how faults in the genetic code are translated into diseases,…

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First in man Tolerance Study launches at Guy’s!

Over the last half century kidney transplantation has become ever more successful, and is now the best treatment for many patients with kidney failure. Early results are outstanding and patients normally leave hospital with a well-functioning new kidney and quickly return to an active life. The main problem for transplant patients and their doctors is that the immune system can reject and destroy the transplanted…

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OuTSMARting the immune system to prevent transplant rejection

  OuTSMART, lead by chief investigator Professor Anthony Dorling, successfully began recruiting patients at Guy’s Hospital in September 2013. This trial is aimed at determining if a combined screening /treatment programme can prevent premature failure of kidney transplants due to chronic rejection in patients with Human Leukocyte Antigen (HLA) antibodies (this is when HLA proteins alert the immune system that a donor kidney is ‘foreign’…

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GAMBIT study

Clinical research is crucial to the advancement of medicine. As an example of one of our many research studies in kidney transplantation, we would like to introduce you to the GAMBIT study which is being carried out at Guy’s hospital. This study received support from the KPA last year as well as long standing support from the Medical Research Council and from Guy’s and St…

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